Family History Key Player in Brain Cancer Risk

Title: Family History Key Player in Brain Cancer Risk
Category: Health News
Created: 9/23/2008 2:00:00 AM
Last Editorial Review: 9/23/2008

Disadvantages

Metronidazole enters an aerobic bacterium where, via the electron transport protein ferrodoxin, it is reduced. The drug then binds to DNA, and DNA breakage occurs. In vitro data suggests metronidazole has antioxidant activity and may prevent and treat rosacea symptoms.

Metronidazole is a nitroimidazole anti-infective medication used mainly in the treatment of infections caused by susceptible organisms, particularly anaerobic bacteria and protozoa. It is considered the gold standard anti-anaerobic agent.

Uses

Yury Bayarski is the contributing author of eMedExpert.com.

It is marketed by Pfizer under the trade name Flagyl in the US, while Sanofi-Aventis markets metronidazole globally under the same tradename, Flagyl. It is also marketed by various generic manufacturers, who sell it at a lower price.

The advantages of metronidazole include:

• High percentage of sensitive Gram-negative anaerobes
• Availability as oral and intravenous dosage forms
• Its rapid bacterial killing properties
• Good tissue penetration
• Considerably low chance of inducing C. difficile colitis
• Price

Mechanism of action

Gold Standard Anti-Anaerobic Medication

• Intra-abdominal infections, including peritonitis, intra-abdominal abscess, and liver abscess
• Skin and skin structure infections
• Bone and joint infections
• Bacterial septicemia
• Endocarditis
• Gynecologic infections (endometritis, endomyometritis, tubo-ovarian abscess, and postsurgical vaginal cuff infection)
• Lower respiratory tract infections (in combination with another agent with activity against microaerophilic Streptococcus)
• Adjunct treatment for gastritis and duodenal ulcer associated with Helicobacter pylori
• Central nervous system infections (meningitis and brain abscess)
• Bacterial vaginosis
• Giardiasis
• Trichomoniasis
• Amebiasis

Advantages

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